<p>&nbsp;</p>

<p>Loss Of Appetite</p>

<p>Eat when you feel hungry. Eat smaller meals frequently than usual. Snack only when you&#39;re hungry. Consult your doctor if the symptom did not improve.</p>

<p><img src="https://www.netmeds.com/images/content/icons/nausea_and_vomiting.jpg" /></p>

<p>Nausea And Vomiting</p>

<p>Stick to simple meals. Avoid eating oily, fried and spicy foods. Do not perform any strenuous activities immediately after eating. Consult your doctor if the symptom did not improve.</p>

<p><img src="https://www.netmeds.com/images/content/icons/stomach_pain.jpg" /></p>

<p>Stomach Pain</p>

<p>Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Consult your doctor if the symptom did not improve.</p>

<h2>WARNING &amp; PRECAUTIONS</h2>

<p><img src="https://www.netmeds.com/images/content/icons/pregnancy.jpg" /></p>

<p>PREGNANCY</p>

<p>CONTRAINDICATED</p>

<p>GLYCIPHAGE G1 FORTE TABLET should not be taken during pregnancy. Consult your doctor before taking GLYCIPHAGE G1 FORTE TABLET if you are planning to become pregnant.&nbsp;</p>

<p><img src="https://www.netmeds.com/images/content/icons/breastfeeding.jpg" /></p>

<p>BREASTFEEDING</p>

<p>CONTRAINDICATED</p>

<p>GLYCIPHAGE G1 FORTE TABLET should not be taken during breastfeeding as it may pass through breast milk. Consult your doctor for advice before taking GLYCIPHAGE G1 FORTE TABLET.</p>

<p><img src="https://www.netmeds.com/images/content/icons/driving_and_using_machines.jpg" /></p>

<p>DRIVING AND USING MACHINES</p>

<p>USE WITH CAUTION</p>

<p>Do not drive or handle any machines if you experience low or high blood sugar levels (symptoms include dizziness, tiredness, shaking or trembling) or if you develop visual problems due to altered blood sugar levels.</p>

<p><img src="https://www.netmeds.com/images/content/icons/alcohol.jpg" /></p>

<p>ALCOHOL</p>

<p>CONSULT YOUR DOCTOR</p>

<p>Avoid consumption of alcohol during treatment with GLYCIPHAGE G1 FORTE TABLET as it may increase or decrease the blood sugar lowering action of GLYCIPHAGE G1 FORTE TABLET and increases the risk of lactic acidosis. Consult your doctor for advice before taking GLYCIPHAGE G1 FORTE TABLET.</p>

<p><img src="https://www.netmeds.com/images/content/icons/kidney.jpg" /></p>

<p>KIDNEY</p>

<p>CONSULT YOUR DOCTOR</p>

<p>GLYCIPHAGE G1 FORTE TABLET is not recommended for use in patients with severe kidney disease and it should be used with caution in patients with kidney disease and your dose will be adjusted if needed depending upon kidney function. Consult your doctor before taking GLYCIPHAGE G1 FORTE TABLET.</p>

<p><img src="https://www.netmeds.com/images/content/icons/liver.jpg" /></p>

<p>LIVER</p>

<p>CONSULT YOUR DOCTOR</p>

<p>GLYCIPHAGE G1 FORTE TABLET is not recommended if you have severe liver disease and it should be used with caution in patients with liver disease and your dose will be adjusted if needed depending upon liver function. Consult your doctor before taking GLYCIPHAGE G1 FORTE TABLET.&nbsp;</p>

<p><img src="https://www.netmeds.com/images/content/icons/allergy.jpg" /></p>

<p>ALLERGY</p>

<p>CONTRAINDICATED</p>

<p>Do not take GLYCIPHAGE G1 FORTE TABLET if you are allergic (hypersensitive) to Glimepiride or Metformin or other sulfonylureas (such as glipizide, glibenclamide) or sulfonamides (such as sulfamethoxazole).</p>

<p><img src="https://www.netmeds.com/images/content/icons/heart_disease.jpg" /></p>

<p>HEART DISEASE</p>

<p>CONTRAINDICATED</p>

<p>GLYCIPHAGE G1 FORTE TABLET is not recommended for use in patients with acute heart problems or recently had a heart attack or have severe circulatory problems or breathing difficulties (signs of heart failure). Consult your doctor before taking GLYCIPHAGE G1 FORTE TABLET.</p>

<p><img src="https://www.netmeds.com/images/content/icons/use_in_pediatrics.jpg" /></p>

<p>USE IN PEDIATRICS</p>

<p>CONTRAINDICATED</p>

<p>GLYCIPHAGE G1 FORTE TABLET is generally not recommended for use in children and adolescents (under 18 years of age). Consult your child&rsquo;s doctor for advice.</p>

<p><img src="https://www.netmeds.com/images/content/icons/use_in_geriatrics.jpg" /></p>

<p>USE IN GERIATRICS</p>

<p>CONSULT YOUR DOCTOR</p>

<p>GLYCIPHAGE G1 FORTE TABLET is not recommended for use in elderly patients (aged 75 years and above) and it should be used with caution in elderly patients (aged 65 years or above), especially in patients with impaired kidney function. Your doctor may assess your kidney function more frequently during treatment with GLYCIPHAGE G1 FORTE TABLET. Consult your doctor before taking GLYCIPHAGE G1 FORTE TABLET.</p>

<h2>OTHERS</h2>

<p>GLYCIPHAGE G1 FORTE TABLET is not recommended for use, if you have:</p>

<ul>
<li>Type 1 diabetes mellitus</li>
<li>Diabetic ketoacidosis</li>
<li>Diabetic coma</li>
<li>Uncontrolled diabetes with nausea, vomiting, rapid weight loss, diarrhea, lactic acidosis (lactic acid build up in the bloodstream) or ketoacidosis (ketone bodies accumulate in the blood)</li>
<li>Dehydration</li>
<li>Severe infection (such as infection affecting lungs or kidneys)</li>
</ul>

<p>Before taking GLYCIPHAGE G1 FORTE TABLET, inform your doctor if you:</p>

<ul>
<li>Are recovering from injury, operation, infections with fever or from other forms of stress</li>
<li>Have glucose-6-phosphate dehydrogenase (G6PD) deficiency</li>
<li>Have various factors which could increase the risk of low blood sugar levels (such as undernourishment, irregular mealtime, missed or delayed meal or period of fasting, change in diet, hormone-induced disorders)</li>
</ul>

<h2>INTERACTIONS</h2>

<p><strong>A. Drug-Drug interactions:</strong></p>

<p>Before taking GLYCIPHAGE G1 FORTE TABLET inform to your doctor, if you are taking any of these medicines:</p>

<ul>
<li>Other sulphonylureas such as glibenclamide, insulin (used to lower blood sugar levels)</li>
<li>Anabolics (supports muscle build up)</li>
<li>Warfarin (treats blood clot)</li>
<li>Fenfluramine (used to reduce weight)</li>
<li>Phenylbutazone, azopropazone, oxyphenbutazone (treats pain and inflammation)</li>
<li>Disopyramide (treats heart problems)</li>
<li>Fibrates such as fenofibrate, nicotinic acid, colesevelam (lowers high cholesterol level)</li>
<li>Angiotensin-converting enzyme (ACE) inhibitors such as captopril, lisinopril, diuretics such as furosemide, chlorthalidone, hydrochlorothiazide or diazoxide (treats blood pressure)</li>
<li>Fluoxetine, monoamine oxidase inhibitors such as isocarboxazid, selegiline and chlorpromazine (used to treat mental disorders)</li>
<li>Allopurinol, probenecid, sulfinpyrazone (treats gout)</li>
<li>Cyclophosphamide, ifosfamide, trofosfamide (treats cancer)</li>
<li>Tetracyclines (Ex. minocycline, doxycycline), chloramphenicol, fluconazole, miconazole, quinolones (Ex. moxifloxacin, ciprofloxacin), clarithromycin, rifampicin (treats bacterial and fungal infections)</li>
<li>Tritoqualine, glucocorticoids (Ex. beclomethasone, hydrocortisone) (treats nasal allergies)</li>
<li>Pentoxifylline in high doses of intravenous infusion (used to improve blood flow)</li>
<li>Sulfonamides such as sulfamethoxazole (treats urinary infections)</li>
<li>Medicines used for male sex hormone replacement therapy (Ex. testosterone) and medicines containing female sex hormones (Ex. oestrogens, progestogens)</li>
<li>Sympatholytics such as clonidine, methyldopa (treats high blood pressure, heart failure or prostate symptoms)</li>
<li>Levothyroxine (used to stimulate thyroid gland)</li>
<li>Adrenaline and sympathomimetics such as phenylephrine, norepinephrine (treats life-threatening cardiac arrest and low blood pressure)</li>
<li>Laxatives such as bisacodyl (treats constipation)</li>
<li>Phenytoin (treats fits)</li>
<li>Glucagon (used to treat severely low blood sugar)</li>
<li>Barbiturates such as pentobarbital, amobarbital (treats nervousness and sleep problems)</li>
<li>Acetazolamide (treats increased pressure in the eye)</li>
</ul>

<p><strong>Overdosage:</strong></p>

<p>If you or anyone else accidentally takes too much of GLYCIPHAGE G1 FORTE TABLET, contact your doctor immediately or go to a nearest hospital straight away. Overdosage symptoms of GLYCIPHAGE G1 FORTE TABLET includes risk of low blood sugar levels (in severe cases it may lead to loss of consciousness and coma) and it may cause life-threatening lactic acidosis. Symptoms of lactic acidosis include vomiting, bellyache with muscle cramps, general feeling of not being well with severe tiredness, reduced body temperature, low heartbeat and difficulty in breathing.</p>

<h2>SYNOPSIS</h2>

<table border="0" cellpadding="1" cellspacing="1">
<tbody>
<tr>
<td><strong>Drug</strong></td>
<td>:&nbsp;&nbsp;</td>
<td>Glimepiride, Metformin&nbsp;</td>
</tr>
<tr>
<td><strong>Pharmacological Category</strong></td>
<td>:&nbsp;&nbsp;</td>
<td>Sulfonylureas, Biguanides</td>
</tr>
<tr>
<td><strong>Therapeutic Indication</strong></td>
<td>:&nbsp;&nbsp;</td>
<td>Type-2 Diabetes mellitus</td>
</tr>
<tr>
<td><strong>Dosage Forms</strong></td>
<td>:&nbsp;&nbsp;</td>
<td>Tablet, Capsule</td>
</tr>
</tbody>
</table>

<h2>MORE INFORMATION</h2>

<ul>
<li>Keep the medicine out of reach of children</li>
<li>Store at temperature below 25&deg;C</li>
</ul>

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