<p>&nbsp;</p>

<p>Eye Pain Or Sensitivity</p>

<p>Close your eyes and relax. Do not strain your eyes by looking at mobile phones, laptops, or television. Avoid driving or operating any heavy tools or machines while your vision is blur. Consult your doctor if you experience blurred vision for a prolonged period.</p>

<h2>WARNING &amp; PRECAUTIONS</h2>

<p><img src="https://www.netmeds.com/images/content/icons/pregnancy.jpg" /></p>

<p>PREGNANCY</p>

<p>CONTRAINDICATED</p>

<p>BRINZOTIM EYE DROPS is generally not recommended for use in pregnant women. Therefore, consult your doctor for advice before using it.</p>

<p><img src="https://www.netmeds.com/images/content/icons/breastfeeding.jpg" /></p>

<p>BREASTFEEDING</p>

<p>CONTRAINDICATED</p>

<p>BRINZOTIM EYE DROPS is generally not recommended for use in breastfeeding women. Therefore, consult your doctor for advice before using it.</p>

<p><img src="https://www.netmeds.com/images/content/icons/driving_and_using_machines.jpg" /></p>

<p>DRIVING AND USING MACHINES</p>

<p>USE WITH CAUTION</p>

<p>Do not drive or operate any heavy tools or machines if you experience dizziness or blurred vision after using BRINZOTIM EYE DROPS.</p>

<p><img src="https://www.netmeds.com/images/content/icons/kidney.jpg" /></p>

<p>KIDNEY</p>

<p>CONSULT YOUR DOCTOR</p>

<p>BRINZOTIM EYE DROPS is not recommended for use in patients with severe kidney diseases. It should be used with caution in patients with other minor kidney problems. Therefore, consult your doctor before using it.</p>

<p><img src="https://www.netmeds.com/images/content/icons/liver.jpg" /></p>

<p>LIVER</p>

<p>USE WITH CAUTION</p>

<p>BRINZOTIM EYE DROPS should be used with caution in patients with liver problems. Therefore, consult your doctor before using it.</p>

<p><img src="https://www.netmeds.com/images/content/icons/allergy.jpg" /></p>

<p>ALLERGY</p>

<p>CONTRAINDICATED</p>

<p>Do not use BRINZOTIM EYE DROPS if you are allergic to Brinzolamide, Timolol, sulphonamides (such as glipizide, gliclazide), diuretics (such as furosemide) or to any other beta-blockers (Ex. labetalol).</p>

<p><img src="https://www.netmeds.com/images/content/icons/lungs.jpg" /></p>

<p>LUNGS</p>

<p>CONSULT YOUR DOCTOR</p>

<p>BRINZOTIM EYE DROPS is not recommended for use in patients who currently have or previously had any lung problems such as asthma or COPD. It should be used with caution in patients with breathing difficulties. Therefore, consult your doctor before using it.</p>

<p><img src="https://www.netmeds.com/images/content/icons/heart_disease.jpg" /></p>

<p>HEART DISEASE</p>

<p>CONSULT YOUR DOCTOR</p>

<p>BRINZOTIM EYE DROPS is not recommended for use in patients with heart problems (such as slow or irregular heartbeat or heart failure). It should be used with caution in patients with coronary artery disease. Therefore, consult your doctor before using it.</p>

<p><img src="https://www.netmeds.com/images/content/icons/use_in_pediatrics.jpg" /></p>

<p>USE IN PEDIATRICS</p>

<p>USE WITH CAUTION</p>

<p>BRINZOTIM EYE DROPS should be used with caution in children and adolescents (aged below 18 years). Therefore, consult your doctor before using it.&nbsp;</p>

<p><img src="https://www.netmeds.com/images/content/icons/use_in_geriatrics.jpg" /></p>

<p>USE IN GERIATRICS</p>

<p>USE WITH CAUTION</p>

<p>BRINZOTIM EYE DROPS should be used with caution in elderly patients. Therefore, consult your doctor before using it.&nbsp;</p>

<h2>OTHERS</h2>

<p>BRINZOTIM EYE DROPS is not recommended for use if you:</p>

<ul>
<li>Have severe allergic rhinitis (hay fever causing nasal block, repeated sneezing, red, watery itching eyes)</li>
<li>Have hyperchloremic acidosis (a condition where there is too much of acidity in blood)</li>
</ul>

<p>Before using BRINZOTIM EYE DROPS, inform your doctor if you:</p>

<ul>
<li>Have low blood pressure</li>
<li>Have Raynaud&rsquo;s disease (poor blood circulation to hands and feet)</li>
<li>Have diabetes</li>
<li>Have an overactivity of thyroid gland</li>
<li>Have muscle weakness</li>
<li>Have dry eyes or problems in your cornea</li>
<li>Wear soft contact lenses</li>
<li>Have any surgery in the upcoming days</li>
<li>Have atopy (a tendency to develop allergic reaction very easily)</li>
</ul>

<h2>INTERACTIONS</h2>

<p><strong>A.</strong>&nbsp;<strong>Drug-Drug interactions:</strong></p>

<p>Before using BRINZOTIM EYE DROPS, inform your doctor if you are taking any of the following medicines such as:</p>

<ul>
<li>Other carbonic anhydrase inhibitors (used to treat glaucoma) Ex. acetazolamide and brinzolamide</li>
<li>Medicines used to treat hypertension and other heart problems (such as clonidine, guanetidine, nifedipine, verapamil or diltiazem)</li>
<li>Amiodarone, digoxin, quinidine (medicines used to treat irregular heartbeat)</li>
<li>Medicines used to treat stomach ulcers (such as ranitidine, pantoprazole)</li>
<li>Adrenaline (a medicines used to treat hypersensitivity reactions)</li>
<li>Other beta-blockers (used to treat hypertension or glaucoma) such as pindolol, labetalol, propranolol, atenolol etc.</li>
<li>Medicines used for depression (such as fluoxetine and paroxetine)</li>
<li>Medicines used to treat diabetes (such as metformin, insulin)</li>
<li>Medicines used to treat viral infections (such as ritonavir, nelfinavir, atazanavir)</li>
<li>Medicines used to treat fungal infections (such as ketoconazole, fluconazole, itraconazole)</li>
<li>Medicines used to treat bacterial infections (such as amoxicillin, cefixime, azithromycin, clarithromycin)</li>
</ul>

<p><strong>Overdosage:</strong></p>

<p>If you or anyone else accidentally used more BRINZOTIM EYE DROPS, rinse your eye with warm water. If still irritation persists, consult your doctor. If you or anyone else accidentally swallowed this medicine, contact your doctor or visit the nearby hospital. Symptoms of overdosage might include headache, dizziness, difficulty in breathing, slow heart rate and chest pain.</p>

<h2>SYNOPSIS</h2>

<table border="0" cellpadding="1" cellspacing="1">
<tbody>
<tr>
<td><strong>Drug</strong></td>
<td>:&nbsp;&nbsp;</td>
<td>Brinzolamide, Timolol</td>
</tr>
<tr>
<td><strong>Pharmacological Category</strong></td>
<td>:&nbsp;&nbsp;</td>
<td>Carbonic anhydrase inhibitors, Beta-blockers</td>
</tr>
<tr>
<td><strong>Therapeutic Indication</strong></td>
<td>:&nbsp;&nbsp;</td>
<td>Glaucoma, Ocular hypertension</td>
</tr>
<tr>
<td><strong>Dosage Forms</strong></td>
<td>:&nbsp;&nbsp;</td>
<td>Eye drops</td>
</tr>
</tbody>
</table>

<h2>MORE INFORMATION</h2>

<ul>
<li>Keep BRINZOTIM EYE DROPS out of reach of children</li>
<li>Store BRINZOTIM EYE DROPS at room temperature</li>
</ul>

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