ALGEST SR 300MG TABLET contains Progesterone which belongs to the group of medicines called Steroid hormones. It supplements your body with extra progesterone during the treatment of infertility that is caused due to progesterone deficiency or while you are undergoing any assisted fertility procedure.

It can also be used to support new pregnancy by maintaining the thickness of the uterine lining. It helps to prevent threatened abortions and pre-term delivery by increasing the serum progesterone level.

It also treats problems associated with progesterone deficiency such as abnormal uterine bleeding, secondary amenorrhea (lack of periods due to hormonal problems or problems in the genital organs), natural cessation of menstruation in women) and used in combination with estrogen therapy to treat menopausal disorders.

Before taking ALGEST SR 300MG TABLET inform your doctor if you have any liver, heart or kidney problems, diabetes, asthma, epilepsy, or depression. Do not take ALGEST SR 300MG TABLET if you have or previously had breast cancer, uterine cancer, unexplained vaginal bleeding, or blood clots. During treatment with ALGEST SR 300MG TABLET, your doctor will instruct you to have periodic blood tests and regular physical examination (breast and uterine examination) as a precaution.

ALGEST SR 300MG TABLET may be prescribed by your doctor during early stages of pregnancy to support the growth of fetus. However, consult your doctor before taking it. ALGEST SR 300MG TABLET is not recommended for use in breast-feeding women and in children and adolescents (below 18 years of age).

The most common side effects of taking ALGEST SR 300MG TABLET are headache, hair loss, pain in the breast, stomach or abdominal cramps, bloating, nausea, vomiting, irregular vaginal bleeding or spotting, fluid retention and vaginal yeast infection. Consult your doctor if any of the side effect worsens.

USES OF ALGEST SR 300MG TABLET


Treats female infertility and other progesterone deficiency states such as abnormal uterine bleeding, menopausal disorders and secondary amenorrhea
Supports early pregnancy
Prevents threatened abortions and pre-term delivery


HOW ALGEST SR 300MG TABLET WORKS

ALGEST SR 300MG TABLET is a steroid hormone used to treat progesterone deficiency in the body. It supplements your body with sufficient levels of progesterone that is required for a successful implantation of fertilized egg in the uterus and for the maintenance of an early pregnancy.

It sustains pregnancy among infertile women by increasing the thickness of uterine wall. It also regulates hormonal balance in the body and corrects abnormal uterine bleeding and other menstrual problems caused due to incorrect levels of progesterone in the body.

DIRECTIONS FOR USE

Take ALGEST SR 300MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you based upon your age, body weight and disease condition.

SIDE EFFECTS OF ALGEST SR 300MG TABLET

COMMON


Headache
Breast pain
Irregular vaginal bleeding or spotting
Stomach or abdominal cramps, bloating, nausea, vomiting, constipation
Hair loss
Fluid retention
Vaginal yeast infection


Stop taking ALGEST SR 300MG TABLET and contact your doctor immediately if you experience any of the following side effects:


Signs of liver disease (such as yellow skin or white of the eyes)
Severely high blood pressure (signs include headache, tiredness and dizziness)
Migraine-like headaches (happening for the first time)
Sudden or gradual, partial, or complete loss of eyesight
Bulging of one or both eyes, double vision
Swelling of the optic nerve
Retinal vascular lesions (eye diseases)
Signs of blood clot (such as painful swelling and redness of the legs, sudden chest pain and trouble breathing)


HOW TO MANAGE SIDE EFFECTS



Constipation

Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly (such as daily walk). Consult your doctor if the symptom does not improve.



Headache

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.



Nausea And Vomiting

Take ALGEST SR 300MG TABLET with or just after meals. Stick to simple meals. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.

WARNING & PRECAUTIONS



PREGNANCY

SAFE

ALGEST SR 300MG TABLET can be taken by pregnant women to support the growth of fetus during the early stages of pregnancy. However, consult your doctor before taking it.



BREASTFEEDING

CONTRAINDICATED

ALGEST SR 300MG TABLET is not recommended for use during breast-feeding. Therefore, consult your doctor before taking it.



DRIVING AND USING MACHINES

USE WITH CAUTION

Do not drive or operate any machines if you feel dizzy or drowsy after taking ALGEST SR 300MG TABLET.



KIDNEY

USE WITH CAUTION

ALGEST SR 300MG TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking ALGEST SR 300MG TABLET.



LIVER

CONSULT YOUR DOCTOR

ALGEST SR 300MG TABLET is not recommended for use in patients who had or have liver disease and with abnormal liver function test. It should be used with caution in patients with benign liver tumor. Therefore, consult your doctor before taking ALGEST SR 300MG TABLET.



ALLERGY

CONTRAINDICATED

Do not take ALGEST SR 300MG TABLET if you are allergic to Progesterone.



LUNGS

CONSULT YOUR DOCTOR

ALGEST SR 300MG TABLET is not recommended for use in patients who had or have blood clot in the lungs (pulmonary embolism). It should be used with caution in patients with asthma. Therefore, consult your doctor before taking ALGEST SR 300MG TABLET.



HEART DISEASE

CONSULT YOUR DOCTOR

ALGEST SR 300MG TABLET is not recommended for use in patients with recent heart attack or chest pain. It should be used with caution in patients with high blood pressure. Therefore, consult your doctor before taking ALGEST SR 300MG TABLET.



USE IN PEDIATRICS

CONTRAINDICATED

ALGEST SR 300MG TABLET is not recommended for use in children and adolescents (under 18 years of age). Therefore, consult your doctor before administering in children.



USE IN GERIATRICS

USE WITH CAUTION

ALGEST SR 300MG TABLET should be used with caution in elderly patients. Therefore, consult your doctor before taking ALGEST SR 300MG TABLET.

OTHERS

ALGEST SR 300MG TABLET is not recommended for use if you:


Have known or suspected cancer of the breast or womb lining (endometrium)
Have unusual vaginal bleeding
Had or have blood clots in the legs (deep venous thrombosis) or in the veins (thrombosis)
Have bleeding on the brain (cerebral hemorrhage) or stroke
Have blood clotting disorder (like protein C, protein S, or antithrombin deficiency)
Have porphyria (rare genetic blood disorder)


Before taking ALGEST SR 300MG TABLET, inform your doctor if you:


Have problems in your uterus (such as fibroid growths or endometriosis (womb lining growth outside your womb)
Have a history of excessive womb lining growth (endometrial hyperplasia)



Have increased risk of blood clot formation (when you are unable to walk for long time after major surgery, injury or illness, obese and older age)
Have a family history of having breast cancer
Have diabetes
Have gallstones
Have migraine or severe headaches
Have systemic lupus erythematosus (an immune system disease that affects many organs of the body)
Have epilepsy (fits)
Have otosclerosis (disease affecting the eardrum and hearing)
Have ever had depression
Have skin sensitivity towards light


INTERACTIONS

A. Drug - Drug interactions:

Before taking ALGEST SR 300MG TABLET, inform your doctor if you are taking any of the following medicines:


Medicines used to treat epilepsy (Ex. carbamazepine, phenytoin, phenobarbital)
Medicines used to treat bacterial infections (Ex. rifampicin, rifabutin, ampicillin and tetracyclines such as doxycycline, minocycline)
Medicines used to treat HIV infection (Ex. nelfinavir, nevirapine, efavirenz, ritonavir)
St. John’s Wort (a medicine used to treat depression)
Bromocriptine (a medicine used to stop breast milk production, treat infertility or parkinsonism)
Cyclosporine (a medicine used to prevent graft rejection)
Medicines used to treat fungal infections (Ex. griseofulvin, ketoconazole, terbinafine)
Spironolactone (a medicine used to treat fluid retention)
Other progesterone medicines used to treat hormonal problems (such as medroxyprogesterone acetate and megestrol)
Medicines used to prevent or treat blood clots blood (Ex. warfarin, phenindione)
Medicines used to treat diabetes (Ex. glimepiride, metformin)
Ulipristal (a medicine used to prevent pregnancy in emergencies)
Tizanidine (a medicine used to treat multiple sclerosis)


B. Drug – Food interactions:

Do not take ALGEST SR 300MG TABLET with food as it may increase the bioavailability of this medicine.

Overdosage:

If you or anyone else accidentally take too much of ALGEST SR 300MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are dizziness, tiredness, drowsiness or sleepiness.

SYNOPSIS




Drug
:  
Progesterone


Pharmacological Category
:  
Progestins (female hormones)


Therapeutic Indication
:  
Treats female infertility, dysfunctional uterine bleeding, menopausal disorders (in combination with estrogen therapy), secondary amenorrhoea, for maintenance of pregnancy, prevents threatened abortion and pre-term delivery


Dosage Forms
:  

Tablet, Soft gel Capsule, Pessaries, Injection, Vaginal Gel, Vaginal spray

MORE INFORMATION


Keep ALGEST SR 300MG TABLET out of reach of children
Store ALGEST SR 300MG TABLET at room temperature